1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Here are the key drug-food interactions:
Here are the key drug-food Interactions:
Introduction:The use of Cialis (tadalafil) is a well-known treatment for erectile dysfunction (ED) in men. However, its use in the context of ED also carries a risk for men with certain medical conditions, such as cardiovascular disease or diabetes. The aim of this study was to investigate the effect of Cialis on men with ED and to compare the impact on men with ED who take the drug.
Methods:A prospective, randomized, placebo-controlled, cross-over study of Cialis (Tadalafil) was conducted in the department of rehabilitation medicine at the Department of Rehabilitation Medicine, University of Florence, Italy. The study was conducted between December 2011 and September 2012 and was approved by the ethics committee of the University of Florence. Patients were recruited in two independent clinics. A total of 906 men with ED and 669 men with ED in the index ED were randomly enrolled into the study. The study was conducted in accordance with the principles expressed in the Declaration of Helsinki. Written informed consent was obtained from all the participants. The study was conducted in accordance with the ethical principles expressed in the Declaration of Helsinki. Study procedures were conducted in accordance with the ethical principles expressed in the Declaration of Helsinki. Informed consent was obtained from all the participants. Participants were excluded if they had diabetes, cardiovascular diseases, severe hypertension, and any other health-related conditions, such as prostate cancer, liver disease, or kidney failure. Moreover, participants who had taken any drug for ED or who were taking any other medications were excluded. The study protocol was approved by the institutional review board of the university of Florence, Italy. All the participants gave their written informed consent.
Results:Cialis (Tadalafil) significantly decreased the time to the onset of sexual intercourse in men with ED compared to placebo. The use of Cialis (Tadalafil) also increased the time to the onset of sexual intercourse in men with ED. The duration of sexual intercourse, the number of erections per session, and the duration of sexual intercourse were statistically significant in the group treated with Cialis (P = 0.008, P < 0.001, P < 0.001, respectively). The mean number of erections per session was reduced from 22.4 to 16.9 (P < 0.001). The duration of sexual intercourse was significantly shorter in the group treated with Cialis (P = 0.001).
Conclusions:Cialis (Tadalafil) can significantly affect the duration of sexual intercourse, the number of erections per session, and the number of erections per session in men with ED. The effects of Cialis (Tadalafil) may be attributed to its effect on the blood flow to the penile tissues and the corpus cavernosum, which may be impaired by the ED drugs.
Citation:Diamantu A, Cipa R, Talaveri P, Vardi A, Mazzola A (2012) Effect of Cialis (Tadalafil) on the duration of sexual intercourse in men with erectile dysfunction (ED). PLoS ONE 11(9): e0183523. https://doi.org/10.1371/journal.pone.0183523
Editor:Piotrk Raspberryi, University of Oxford, UNITED STATES
Received:December 11, 2012;Accepted:May 30, 2013;Published:June 12, 2013
Copyright:© Diamantu et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:The study was supported by the University of Florence. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
The Drug Facts:Cialis 20 mg Tablet contains Tadalafil (as Cialis). It is an erectile dysfunction (ED) medication used to treat erectile dysfunction in men. The active ingredient in Cialis is Tadalafil 20 mg.
What is Cialis 20 mg?
Cialis 20 mg is an oral medication used to treat erectile dysfunction (ED) in men. It is a type of phosphodiesterase type 5 (PDE5) inhibitor. This medication works by increasing blood flow to the penis when sexually aroused. This helps to maintain and increase the blood flow needed to achieve an erection when sexually stimulated. This medication is available in tablets, capsules, and liquid suspension.
How does Cialis 20 mg work?
Cialis 20 mg is a phosphodiesterase type 5 (PDE5) inhibitor that helps relax the blood vessels in your penis, allowing more blood to flow into your penis when you are sexually aroused. This allows you to achieve and maintain an erection for sexual activity.
What is the best way to take Cialis 20 mg?
Cialis 20 mg tablets are a type of PDE5 inhibitor that allows the blood vessels in your penis to relax. This allows more blood to flow into your penis when you are sexually aroused. You should take Cialis 20 mg with a meal or snack as directed by your doctor. Do not take more than one dose of Cialis 20 mg in a 24-hour period.
What are the benefits of Cialis 20 mg?
The most significant benefits of Cialis 20 mg are that it can work within 30 minutes to an hour after taking it. This makes it a popular choice for those who are looking for an effective and quick medication for ED.
How long does Cialis 20 mg last?
The effects of Cialis 20 mg can last for up to 36 hours. You can take Cialis 20 mg with or without food. The medication does not require any alcohol. However, it is important to avoid consuming grapefruit or grapefruit juice while taking Cialis 20 mg. It is also important to follow your doctor’s instructions carefully and to take the medication exactly as prescribed by your doctor.
Cialis 20 mg works by relaxing the blood vessels in your penis, allowing more blood to flow into your penis when you are sexually aroused. This helps you achieve and maintain an erection for sexual activity. The medication does not cause spontaneous erections in response to sexual stimulation.
Cialis 20 mg works by inhibiting the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). cGMP, a chemical messenger in your body, relaxes the smooth muscle cells in the penis, allowing more blood to flow into the spongy tissue of the penis. This causes an erection for up to 36 hours.
Is Cialis 20 mg safe?
Cialis 20 mg is generally considered safe to use when used as prescribed by your doctor. However, it is important to follow your doctor’s instructions carefully and to take the medication exactly as prescribed by your doctor.
It is generally safe to use Cialis 20 mg when taken as directed by your doctor.
Tadalafil, also known as Cialis, is a medication that is used to treat erectile dysfunction (ED) in men. It works by relaxing the blood vessels in the penis, allowing more blood to flow into it when sexually aroused. This helps to achieve and maintain an erection.
Tadalafil comes in two forms, and it's widely available and widely prescribed. The first is called generic Cialis. It's available in 20mg, 30mg and 40mg pills. Generic Cialis is usually recommended for men who have difficulty with sexual performance, such as those who have difficulty with erectile dysfunction.
The second is called tadalafil Soft. This is also available as a tablet, but it's not the same. It's usually recommended for men who have difficulty with erectile dysfunction.
Tadalafil Soft is often prescribed for men who experience erectile dysfunction. It's available as a tablet, which is usually taken on an as-needed basis, or it's usually taken only when needed. It can also be bought as a chewable tablet, which is often prescribed for men who have difficulty with erectile dysfunction.
Tadalafil is known for its ability to improve blood flow to the penis. This allows for more blood to enter the penis and help achieve an erection. It also helps to achieve and maintain a firm erection during sexual stimulation.
The effectiveness of tadalafil is comparable to that of other ED medications, which may be due to different factors. For example, tadalafil can help to maintain an erection when stimulated, but it can also help to temporarily decrease the frequency of sexual activity. This can help men who have difficulty with erectile dysfunction gain confidence and improve their sexual performance.
Tadalafil is generally considered safe, but it's important to note that it's not a suitable treatment for all men. It's always recommended to consult with a doctor before starting any treatment.
Tadalafil Chewable TabletsTadalafil Chewable Tablets are a form of Cialis that can be taken with or without food, though they are not as effective as Tadalafil Soft. However, it is essential to remember that it can take up to an hour to kick in, so it's not recommended to take it for more than an hour. This can be especially important for men who prefer to have their erections maintained longer, such as those who have trouble with their erection during sexual activity. Tadalafil Chewable Tablets should be used in combination with sexual stimulation, so it is not recommended to combine it with sexual activity.
The chewable form of tadalafil is usually recommended for men who have trouble with their erections, such as those who have difficulty with erectile dysfunction. This is because it's not as effective as the tablet form, which is designed for men who have difficulty with erectile dysfunction.
The chewable form of tadalafil is not suitable for men who take nitrates, so tadalafil should not be used if you have a history of chest pain, heart conditions or liver disease. It's also not suitable for those who have taken nitrates in combination with any form of nitroglycerin.
The chewable form of tadalafil is not suitable for men who have experienced side effects with any form of nitrates or nitroglycerin. This is because the effects of the drug are more pronounced when you take it with a high-potency, high-dose combination of the nitrates and the drug. If you have had a heart attack or stroke in the last 6 months, or if you have high blood pressure in the past 12 months, or if you are taking other medications that have been prescribed for you, such as alpha-blockers, you should not take tadalafil.
Tadalafil Chewable Tablets Chewable TabletsTadalafil Chewable Tablets can be taken with or without food, though it can be taken with or without food, as well as in small doses. It is generally recommended to take tadalafil Soft for those who have difficulty with erectile dysfunction. It is available in the same dose as Cialis and is usually taken about an hour before sexual activity.
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